Surface active poly(ethylene glycol)-based biocompatible block copolymer micelles
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초록
내용
Polymer nanoparticles made from amphiphilic copolymers can form monolayers by locating at the surface of liquids. Due to their ability to reduce dynamic air/liquid interfacial tension, similar to the state of alveoli, they can be considered as non-phospholipid surfactants that circumvent the long-standing issue of native phospholipid surfactants destabilization caused by respiratory diseases. Herein, we design a clinically adaptable block copolymer of biocompatible poly(ethylene glycol) (PEG) and biodegradable poly(decalactone) (PDL). The synthesis and micelle formation process of PEG-PDL copolymers are systematically studied by varying the experimental conditions. Then, we address the performance of PEG-PDL copolymers at the air/water interface and compare it with that of a general PEG-based copolymer, poly(styrene-block-ethylene glycol) (PS-PEG). An excellent surface-active property of the PEG-PDL micelles at the air/water interface, similar with the PS-PEG, is expected.