Poly(acrylic acid)-based Tissue Adhesives with Enhanced Adhesive Properties
발표자
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초록
내용
Tissue adhesives offer unscarred post-surgical results, simplicity, and unnecessary needs for a separate removal process. However, they have weak adhesion in wet condition. Carbopol® is a crosslinked polymer derived from poly(acrylic acid) (PAA) with exceptional water absorption and biocompatibility. This study aimed to improve tissue adhesion under wet conditions by introducing N-hydroxysuccinimide (-NHS) groups into Carbopol® via EDC/NHS coupling reaction. The modification confirmed through FT-IR and 1H NMR analyses on Carbopol®, NHS, and Carbopol-NHS. In the in vitro MTT assay, both Carbopol® and Carbopol-NHS demonstrated cell viability exceeding 80% under 1% dilution conditions. The tissue adhesion properties of Carbopol-NHS were evaluated using UTM and rheometer. Each molar ratio of NHS to -COOH groups in Carbopol® revealed a direct correlation between increased NHS content and increased tissue adhesion force.