Gelatin-releasable alginate bioink for improving osteogenic differentiation
발표자
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초록
내용
In this study, we aimed to enhance the osteogenic activity of a hydrogel by combining the release and retention of gelatin, so that gelatin performs two roles: it provides direct support for encapsulated cells inside a printed hydrogel, as well as an indirect support by released ink component on adjacent cells. Because of its modest effect on cell adherence, methacrylated-modified alginate (MA-ALG) was selected as the matrix. From the results, the entrapped gelatin in MA-ALG could remain for up to 21 days. The released gelatin affected the external cells, showing more favorable osteogenic behavior than the control sample Also, the remained gelatin showed positive effects in cell proliferation and osteogenic differentiation on encapsulated cells. It was also found that this multi-component hydrogel could use as a bioink for printing with high cell viability. Therefore, we anticipate that the developed bioink in this study, could be used to induce osteogenesis in tissue regeneration.