Stimuli-responsive polyurethanes for bioresorbable electronic medicine
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초록
내용
Recent advancements in transient devices have led to the development of bioresorbable electronic medicine, which eliminates the need for explant surgeries and reduces the risk of infection. However, conventional polymeric encapsulations often face issues of premature device failure or prolonged residual presence due to their hydrolysis-based “passive” degradation. Here, we introduce a novel stimuli-responsive polyurethane designed for “active” degradation of electronic medicine. This material, called bioresorbable glutathione-responsive polyurethane (b-GrPU), employs disulfide bonds to trigger degradation in the presence of the biological antioxidant glutathione. Studies demonstrate the stimuli-responsive characteristics of b-GrPU through its mechanical and chemical properties. Systematic tests as an encapsulation material for electronic medicine show its ability to sustain operation with controllable durations ranging from a few hours to a week while immersed in aqueous solutions.