Optimizing the Design of 3D Printed Tracheal Scaffolds: Integrating FEA Simulations and Bioprinting for Enhanced Functionality with Biological Cues
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초록
내용
Various tracheal substitutes have been investigated; however, methods for reconstructing a damaged trachea encounter significant challenges, including low biocompatibility and compromised physical properties after implantation. To address these issues, we proposed a novel mech-body hybrid scaffold structure using 3D & bioprinting. Finite element analysis (FEA) simulations were conducted to optimize the design of the 3D printed polycaprolactone (PCL) scaffold and establish a comprehensive library of physical properties. Furthermore, a photo-crosslinkable chitosan-gallol-based bioink with Cartilage and Mucosa dECM was bioprinted with visible light (blue light). These bioinks were able to promote differentiation of AdMSCs into cartilage and mucosal tissues. The hybrid tracheal scaffold of 3D printed PCL and bioprinted dECM bioinks demonstrated promising results for tracheal regeneration.