Enhancing biological half-life of growth factors using ROS-scavenging sticky coacervate
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초록
내용
Effective tissue regeneration relies on communication between cells through secretomes, while maintaining reactive oxygen species (ROS) levels. However, the short retention times and half-lives of secretomes at injection sites, along with excessive ROS generated during the tissue regeneration, pose significant challenges. The Coating Optimized Drug Delivery Enhancement (COD2E) system addresses these issues by providing an efficient delivery mechanism for therapeutic agents and exhibiting ROS scavenging properties. Comprising dopamine-functionalized fucoidan and poly-L-lysine, COD2E enables rapid and uniform coating on various substrates, enhancing the stability and release profile of encapsulated agents, such as fibroblast growth factor 2. This study demonstrates that COD2E improves cell viability, promotes tissue repair, and modulates oxidative stress, indicating its potential platform for enhancing secretome therapies in regenerative medicine.