Artificial Octopus-Limb-Like Adhesive Patches for Cupping-Driven Transdermal Delivery with Nanoscale Control of Stratum Corneum
발표자
()
초록
내용
Transdermal drug delivery systems are currently under investigationto achieve long-term and stable targeted therapy more simply. However, the challenge posed by the stratum corneum barrier often regarded as the primary obstacle of TDDS remains unresolved, resulting in a notable decline in drug delivery efficiency. Here, we introduce a noninvasive and powerless transdermal drug delivery patch fabricated with a double-layer suction chamber cluster (d-SCC) inspired from octopus-limb which exhibits improved wet adhesion performance through simple preload application. This patch can effectively achieve transdermal drug delivery through the stratum corneum without skin stimulation by causing nanoscale deformation of the stratum corneum. We confirmed the improved drug delivery depth by using a confocal microscope. Then, we confirmed the efficacy of d-SCC, exhibiting superior maltol delivery and the level of AD therapy compared to other groups in AD-induced rats.