3D Printed Assemblable Scaffold as a Versatile Microcryogel Carrier for Site-Specific Regenerative Medicine
발표자
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초록
내용
Here, we fabricated an hive-structured assemblable scaffold (HIVE). HIVE can be manually assembled in any shape/size with ease, so a surgeon can create a scaffold that would best fit a defect. Simultaneously, it can have site-specific treatments by working as a carrier filled with microcryogels (MC) incorporating different biological factors in different pockets of HIVE. After characterization, we investigated possible site-specific applications by utilizing HIVE as a versatile carrier with incorporated treatments such as growth factors (GF), bioceramic or cells. A HIVE with different combinations of MCs yielded a distinct local effect and we confirmed successful cell migration within assembled HIVE scaffolds. Finally, an in vivo rat subcutaneous implantation study demonstrated site-specific osteogenesis and angiogenesis. In conclusion, the HIVE fulfills a need for patient-specific treatment by assembly with unlimited combinations and controlling specific effects at local sites.