Assembly-driven enhanced anticancer effect of BerberineBy Sodium Guaiazulene Sulfonate
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Berberine is a versatile natural compound with the potential to treat various pathological conditions. Recently, there has been widespread interest in the anticancer effects of berberine. However, due to the instability of berberine as a drug, there is a limitation in its direct effect on cancer cells, which is relatively weak. To increase stability and enhance efficacy, we present the development of supramolecular anticancer materials based on berberine. Supramolecules were constructed using berberine and sodium guaiazulene sulfonate, a biocompatible natural compound, through ionic bonds and aromatic interactions. The resulting supramolecular anticancer materials induced greater toxicity in Hela cells compared to a single molecule. This supramolecular approach not only provides insights into the assembly of next-generation anticancer agents at the molecular level but also offers a strategy for producing well-defined supramolecular anticancer drugs.