Formation of discrete vesicular assembly of Sorafenib for enhanced anticancer activity
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Sorafenib is known as a multi-tyrosine kinase inhibitor, but it has the disadvantage of low bioavailability due to low water solubility. This study presents the results of the impact of solvent composition on the self-assembled structure of sorafenib and its bioactivity, aiming to address the challenges associated with poor solubility in aqueous conditions. Sorafenib forms large sheets of several tens of micrometers when dissolved in water. However, sorafenib self-assembles into vesicles in a 30% methanol solution with a diameter of approximately 500 nm. The discrete vesicular aggregates enhanced the drug uptake into HepG2 cells and improved the anticancer ability.