Targeted Nitric Oxide Delivery to M1 Macrophages for Reducing Inflammation in Chronic Obstructive Pulmonary Disease
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초록
내용
Chronic obstructive pulmonary disease (COPD), a progressive lung disease, is characterized by chronic inflammation that leads to irreversible structural changes in the lungs and airways. M1 macrophage drives the inflammatory processes characteristic of COPD by releasing pro-inflammatory cytokines. Nitric oxide (NO) regulates inflammation and improves ventilatory efficiency in COPD patients. Therefore, inhalation of NO would be a potential strategy for COPD treatment. However, targeted NO delivery is challenging due to its short half-life and limited diffusion distance. In this study, the surface of silica nanoparticles was modified with hyaluronic acid (HA) and polyethyleneimine (PEI) to deliver NO into M1 macrophages selectively. We confirmed targeted NO delivery to M1 cells by HA and subsequent polarization of M1 to anti-inflammatory phenotype M2. This reprogramming of M1 to M2 alleviated inflammation, making targeted NO delivery system a potential therapeutic agent for COPD.