Bispecific tumor targeting via biomaterial-mediated ex vivo NK cell surface engineering
발표자
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초록
내용
Although a series of immune cell therapies with specific tumor targetability have been investigated, bispecific tumor targeting, especially for solid cancers, is still under development. Therefore, this study aims to design membrane-functionalized natural killer (NK) cells using bispecific solid tumor targeting ligands; 1) hyaluronic acid (HA) for CD44 receptor on pancreatic tumors and 2) phenylboronic acid (PBA) for sialic acid on breast cancers. Developed lipid-PEG-HA-PBA were effectively coated on NK cell surfaces via lipid-lipid interaction without internalization due to the penetration blocker PEG. Our preliminary results envision that the membrane-engineered NK cells exhibit significantly enhanced levels of target cancer recognition and killing efficacy, as compared with naïve NK cells and single ligand-coated NK cells.