Ultra-Sensitive Alzheimer's Biomarker Detection with EGFET Biosensors Using Surface Roughness
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초록
내용
Field effect transistor (FET)- based biosensors are ideal for point-of-care diagnostics, but their sensitivity often declines due to electrical double layers (EDLs) that screen potential changes. To counter this, we enhanced the nanoscale roughness of the sensing membrane surface using a cost-effective, rapid, and selective wet etching process with simple equipment. This nanoscale roughness increased binding sites and minimized Debye screening, thereby boosting the EGFET biosensor's sensitivity. Our study showed that this approach significantly increases sensitivity. Additionally, we used an extended gate field-effect transistor (EGFET) configuration to ensure stable results, which also eliminates the need for a passivation layer, simplifying fabrication and reducing costs. Our method is fast, simple, stable, and economical, making it a promising strategy for improving EGFET biosensors and enhancing the practicality of point-of-care diagnostic devices.