Membrane-immobilized bifunctional peptides on placenta-derived mesenchymal stem cells (PDMSCs) for the treatment of liver cirrhosis
발표자
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초록
내용
Liver cirrhosis (LC) is severe scarring of the liver that has high mortality and morbidity. However, there is no effective therapy at the stage of LC, and liver transplantation is only available. Recently, mesenchymal stem cells (MSCs) showed beneficial efficacies on liver fibrosis. In order to augment angiogenic capability of liver cells, we developed bifunctional peptide-coated placenta-derived MSCs (PD-MSCs). Bifunctional peptides (i. e., Periostin and WKYMVm) was incorporated into lipid-PEG2000-HA and the resulting materials were homogeneously coated on PD-MSCs’ surface. Our bifunctional peptide-coated PDMSCs could exhibit facilitated angiogenesis ability, resulting in the reduction of liver fibrosis without deteriorating the intrinsic properties of PDMSCs. Consequently, our study provides great potential of surface-manipulated stem cells, particularly with the aid of peptide-based biomaterials, for the treatment of liver cirrhosis.