Effect of silica nanoparticle treatment on adhesion between tissue-like substrates and <em>in vivo</em> skin wound sealing
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초록
내용
Silica nanoparticles have been used as innovative solutions of surgical glue that can readily adhere to various tissue-like substrates without complex processes. Herein 10 nm-sized silica nanoparticle(SiNP10) treatment exhibited maximum adhesion strength in the porcine heart tissue model, which was approximately 5.9 times higher than that of the control group. We assessed the effects of silica nanoparticle treatment on in vivo skin wounds sealing. Compared to the commercial cyanoacrylate skin adhesive (Dermabond), we quantified the expression of inflammation, angiogenic growth factors and connective tissue formation-related proteins in incision wound skin. At day 5 after wound closing treatment, the expression levels of PDGF-BB growth factor were significantly higher in SiNP10 treatment (0.64 ± 0.03) compared to Dermabond (0.07 ± 0.05). SiNP10 treatment may be associated with promoting effects on wound closure and tissue adhesion.