Nuclear Magnetic Resonance Spectroscopy for Biodegradation Processes of Microcapsule: Probing Biodegradation Mechanisms and Kinetics
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초록
내용
With an increase in the severity of environmental pollution caused by microbeads, the development of biodegradable microcapsules that can be applied in diverse fields has attracted significant attention. The degradation processes directly relate to biodegradable microcapsule creation with high stability and persistence. In this study, biodegradable microcapsules are synthesized via a complex coacervation approach using gelatin and alginate as the capsule's main materials; additionally, enzyme-induced decomposition is proposed by observing spectral changes in 1H NMR analyses. Close inspection reveals that determination of the degradation rate constant of the major components in the capsule is feasible, and suggests two types of 4-stage degradation mechanisms that are enzyme-specific. These investigations demonstrate that capsule degradation can be explored in detail using 1H NMR to provide a viable strategy for monitoring degradation properties in developing new biodegradable polymers.