One promising shift toward green chemistry has been to replace C8 fluorocarbons with C6 in the coating for favorable health and environmental properties. We present a polymeric coating with C6 that exhibits an excellent nonwetting ability toward chemical warfare agents. A copolymer of PFOMA and EGDMA was directly coated onto a fabric via initated chemical vapor deposition (iCVD). The iCVD-prepared PFOMA copolymeric coating had a rough-textured surface feature on the fabric and exhibited an outstanding nonwetting ability against CWAs. Next, we attempted a new conceptual approach comprising both the introduction of micor/nano geometric structure and surface modification with a hydrophobic chemical. We generated the micro and/or nano-scale surface roughness by growing a metla-oragnic framework, UiO-66-NH2 or Zr(OH)4 on cottong fabric. The surface was coated with a hydrophobic O-POSS. The O-POSS coated UiO-66-NH2 on cottong fabric formed exhibted resistance towards the chemical warfare agent.