Development of peptide-conjugating DNA scaffolds for cooperative inhibition of deadly viruses
발표자
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초록
내용
Recently, various RNA viruses like COVID-19 are frequently occurring around the world, proving that they become threats to individual countries. In particular, Hantavirus has reported high mortality rate; thus, there is a need for developing neutralizing agents that recognize the virus. Because Hantavirus' spike protein molecularly interacts with β3 integrin, one of human cell membrane proteins, prohibition of this interaction would be way to block viral infection. Neutralizing agent can be created using our hotspot-oriented ligand display technology; by implementing structural stabilization and binding optimization of a peptide fragment, which is originated from the hotspot region of β3 integrin, the peptide-conjugating DNA scaffold would achieve high affinity and specificity toward the target virus. Relying on the tetrameric structure of the spike protein,we also explore the potential of tetramerization of hotspot peptide-conjugating DNA scaffold to enhance the viral neutralization.