Phamacokinetic/Immungenic Impact on Polyglycerol-grafting on NPs Compared to PEGylation
발표자
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초록
내용
Polyethylene glycol (PEG) has been extensively used on a variety of nanomaterials systems for biomedical applications, thanks to its unique hydrophilicity and biocompatibility. Grafting PEG on nanoparticle (NP) surface can minimize non-specific interaction of NPs in biological surroundings, evade macrophagic clearance and improve pharmacokinetic properties. However, the concerns on immunogenicity of PEG raised including anti-PEG antibody generation, accelerated blood clearance and pseudo-anaphylaxis. In this presentation, polyglycerol (PG), one of the suggested PEG-alternative polymers has been prepared in linear structure (linPG) or hyperbranched structure (hPG) and grafted on biodegradable polylactic acid NPs (PLA). Pharmacokinetic and immunogenic impacts on PG grafting have been systematically studied and compared with PEG. Notably, the relationship between adaptive immune response and the structural similarity of NP-surface polymer have been observed first time.