Bio-Ink and 3D Printing-based to Mimic of Three-dimensional Skin and Adipose Spheroid Complex with Internal Blood Vessels
발표자
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초록
내용
There are many challenges to find stable printability and maintained high cell viability. The purpose of this study was to develop a 3D artificial composite tissue material and manufacturing technology that simulates blood vessel-derived fat/skin tissue. By combining 1. printing-based skin tissue production technology for fat/skin complex tissue development and 2. spheroid-based adipose tissue production technology, Finally, 3. To establish a 3D artificial composite tissue production and culture technology that simulates adipose tissue linked blood vessels. The results of placing the fat spheroids with green fluorescence micro-particles were shown, and the red fluorescence Rhodamine B material was printed with bio-ink on the adipose tissue structure. The height of the fat/skin complex fabricated through the complex printing process was 1 mm and it is thought that a complex tissue in which skin tissue can be stably formed on the adipose tissue structure.