Pump-Probe Spectroscopy on Intersystem Crossing Dynamicsin Cyanine Derivatives for <sup>1</sup>O<sub>2</sub> Generation
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초록
내용
Photodynamic cancer therapy (PDT) is an emerging non-invasive cancer therapeuic technique. One of its major breakthroughs has been designing better photosensitizer (PS) that effectively generates reactive oxygen species (ROS; molecular singlet oxygen, superoxide radical, hydrogen peroxide, etc.), which are formed as the triplet-state of a photosensitizer (PS) reacts with ground-state 3O2 or adjacent biomolecules. Therefore, high yield and long lifetime of PS triplet-state should be an important factor that determines better tailoring of PSs. In this work, excited-state dynamics regarding the formation and decay of triplet-state for cyanine derivatives (IR-820, XXX) are investigated using pump-probe spectroscopy (fs-TAS and ns-TAS). These results showed that molecular engineering of substituents in cyanine functional groups induces more efficient ROS generation.