Electrostatic interaction between anionic Adapalene and cationic polycaprolactone emulsifier to the treatment of acne vulgaris
발표자
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초록
내용
Adapalene (ADP) has a good therapeutic effect for treatment of acne vulgaris due to inflammatory inhibition and low side effects. This study aimed to increase the stability and therapeutic effect of ADP by using electrostatic interaction. Emulsion using methoxy polyethylene glycol-b-poly(ε-caprolactone) (PC) and PC with amine side group (PC-NH2) as negative and positive charge emulsifiers were prepared to evaluate the effects of acne treatment through electrostatic interaction between emulsifier and ADP. As the number of amine pendant group of PC-NH2 increases, the positive charge potential becomes stronger and the negative charge potential caused by ADP decreases. Therefore, the positively charged PC-NH2 emulsifier can be used as an effective acne treatment strategy through the electrostatic interaction between the negatively charged ADP and the skin.