Safe and efficient brain tumor therapy using polysorbate-based drug carriers
발표자
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초록
내용
Polysorbates are non-ionic surfactants with low toxicity, and their lipophilic nature allows for encapsulation of both hydrophobic and hydrophilic drugs. Moreover, polysorbates can improve drug accumulation in the brain via favorable interaction with brain endothelial cells. In this study, we develop polysorbate (Tween80)-based drug carriers for the treatment of brain and breast tumors. Various anticancer drugs such as kaempferol, doxorubicin, and piperlongumine, were effectively encapsulated in Tween 80-based nanoparticles (NPs). Tween 80-based NPs exhibited high colloidal stability in physiological conditions. The capability of Tween 80-based drug carriers to cross the blood-brain barrier (BBB) was demonstrated by in vitro BBB model. In vitro cytotoxicity studies demonstrated that Tween80-based NPs effectively delivered anticancer agents into cancer cells without adverse effects. This study demonstrates the potential of polysorbate-based NPs for safe and efficient anticancer therapy