In situ synthesized amorphous calcium phosphate nanoparticle incorporated into gelatin-methacryloyl matrix as a potential biomaterial for bone tissue engineering
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초록
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The main challenge with hydrogels is their low mechanical properties which can be improved by adding nanoparticles, such as calcium phosphate (CNP), but their heterogeneous distribution remains a challenge with conventional mixing methods. Here, we synthesized CNP into the gelatin-methacryloyl (GelMA) hydrogel using gelatin as a stabilizing agent, and after synthesizing the nanoparticles, methacrylation step proceeded to prepare CNP/GelMA. Our technique allows for modification of CNP size, distribution, and shape through gelatin concentration changes. Findings from the mechanical analysis and cell culture study showed that the photo-crosslinked 3D-printed CNP/GelMA structure has higher mechanical properties and is preferable for bone tissue engineering. Acknowledgment:This was supported by the National Research Foundation of Korea (NRF) Grant (NRF-2022R1A2C2006341 and 2021H1D3A2A02044451) and Human Resource Development Programs for Green Convergence Technology funded by the Korea Ministry of Environment (MOE).