Peptidomimetic Wet-Adhesive PEGtides with Synergistic and Multimodal Hydrogen Bonding
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The remarkable underwater adhesion of mussel foot proteins has long been an inspiration in the design of peptidomimetic materials. Although the synergistic wet adhesion of catechol and lysine has been recently highlighted, the critical role of the polymeric backbone has remained largely underexplored. Here, we present a peptidomimetic approach using poly(ethylene glycol) (PEG) as a platform to evaluate the synergistic compositional relation between the key amino acid residues as well as the role of the polyether backbone in interfacial adhesive interactions. A series of PEG-based peptides (PEGtides) were synthesized using epoxide monomers corresponding to catechol and lysine via anionic ring-opening polymerization. Our study sheds light on the design of peptidomimetic polymers with reduced complexity within the framework of a polyether backbone.