Sprayable PVA-Modified Ti<sub>3</sub>C<sub>2</sub> MXene/SA Hydrogel for Antibacterial and Wound Healing Drug Release System
발표자
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초록
내용
Skin wounds have good self-healing abilities, but repeated wounds or reduced immunity from aging can reduce wound healing. Prolonged healing increases the risk of infection and causes complications. Researchers are exploring methods to inhibit bacterial infection and improve wound healing to address this. Ti3C2Tx MXene, a 2D nanomaterial with photothermal conversion, antibacterial activity, and ROS generation, has shown promise. This study evaluated the antibacterial effect and wound-healing ability of drugs loaded on PVA-bound MXene. The MXene was surface-modified with PVA, loaded with CIP, mixed with sodium alginate, transferred to an sprayer, and then sprayed with CaCl2 to form a Ciprofloxacin(CIP)-loaded PVA-MXene/SA hydrogel. The hydrogel showed photothermal conversion ability and biocompatibility, and its drug release had antibacterial activity. As a result, the CIP-loaded PVA-MXene/SA hydrogel showed effective wound healing and is a promising material for future tissue engineering.