Molecular interpretation of water impermeability across the liquid-ordered membrane under hypertonic conditions
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The permeation of water molecules across cell membranes plays an essential role in life-sustaining cellular activities. Thus, it is important to explore water permeation driven by the internal composition of the lipid membrane. However, a lack of membrane platforms discourages unveiling the mechanisms of water impermeability across the liquid-ordered domain under hypertonic conditions. Herein, we verified the extremely suppressed water permeation across the liquid-ordered domain by both experimental and simulation approaches. We confirmed that water permeation is suppressed by approximately 37-fold across the liquid-ordered domain compared to the liquid-disordered domain. Simulations further clarified that directional water translocation across the liquid-disordered domain under hypertonic conditions leads to the membrane bursting, which supported the experimental results. Taken together, the experimental and simulation results offer clues for the underlying mechanism of water impermeability across the liquid-ordered domain.