Smart siRNA Nanomedicine with Dynamic Covalent Interaction for Programming Cell Death Mechanism
발표자
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초록
내용
siRNA (small interfering RNA), which knockout pathogenic gene and interfere with specific protein expression, has great potential for treatment of human diseases such as cancers or senescence. However, siRNA delivery to cytosol in target cell remains challenging due to the physiological barriers as poor stability of siRNA and low endosomal escape efficiency. Even if siRNA knockdown the pathogenic gene, the treatment efficiency is limited because the inherent complexity and dynamics of cellular mechanism avoid cell death. Herein, we have developed a smart siRNA nanomedicine that can facilitate intracellular delivery, overcome endosome escape barrier, and even activate cell death signals. Intramitochondrial polymerization induced by disulfide-based siRNA nanomedicine causes mitochondrial damage, which can activate the apoptosis mechanism, thus exceeding the hurdles of the existing siRNA system.