Wireless Theranostic Smart Contact Lens for Monitoring and Control of Intraocular Pressure in Glaucoma
발표자
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초록
내용
Glaucoma is one of the irreversible ocular diseases that can cause vision loss in some serious cases. Tthere is no smart contact lens to monitor intraocular pressure (IOP) and take appropriate drug treatment in response to the IOP levels. Here, we report a precisely integrated theranostic smart contact lens with a sensitive gold hollow nanowire (AuHNW) based IOP sensor, a flexible drug delivery system (DDS), wireless power and communication systems and an application specific integrated circuit (ASIC) chip for both monitoring and control of IOP in glaucoma. The AuHNW based IOP sensor shows high ocular strain sensitivity, chemical stability and biocompatibility. Furthermore, the flexible DDS can be used for on-demand delivery of timolol for IOP control. Taken together, the IOP levels can be successfully monitored and controlled by the theranostic smart contact lens in glaucoma induced rabbits. This theranostic smart contact lens would be harnessed as a futuristic personal healthcare platform for glaucoma and other ocular diseases.