Harnessing extracellular vesicles for therapeutic and diagnostic applications
발표자
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초록
내용
Extracellular vesicles (EVs) are small particles with sizes ranging from 50-1,000 nm that are constantly secreted by cells. As central mediators of intercellular communication, EVs, including exosomes, play important roles in the pathogenesis of various diseases. EVs enter the circulatory system and are therefore found in most body fluids, including blood, urine, saliva, etc. Thus, EVs are promising biomarkers for liquid biopsy to overcome the limitations of previously established biomarkers. Also, recent studies have shown that nano-sized EVs can be engineered to enhance their therapeutic functions and deliver therapeutic drugs. Thus, EVs hold great potential as novel biomaterials that can be used in diagnosis and therapy. In this presentation, I’ll overview the characterization of EVs followed by recent applications of EVs in biomedical uses. The development of novel EV sources and efficient EV concentration method to facilitate the use of EVs as prominent biomaterials for disease diagnosis and therapy will be also introduced.