Multi-shell structured upconversion nanoparticles for near-infrared-mediated synergistic combination cancer therapy
발표자
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초록
내용
Lanthanide-doped upconversion nanoparticles (UCNPs) which are a new generation of fluorescence materials provide numerous advantages for biomedical applications such as bioimaging, disease treatment, drug delivery, and tissue engineering owing to their excellent signal-to-noise ratio, high sensitivity, high photostability, and biocompatibility in various field. Combination cancer therapy has the potential to overcome the therapeutic efficiency of conventional monotherapy through synergistic effects. Photodynamic therapy (PDT) combined with specific cancer immunotherapy has revolutionized cancer treatment due to enhanced anti-tumor immune response. In this study, multi-shell structured UCNPs were prepared by the thermal decomposition method. In addition, the anti-tumor efficacy of combined PDT and cancer immunotherapy with the multi-shell structured UCNPs-based nanocarriers were investigated.