Tuning stickiness on polyelectrolyte nanocarriers to target cells and tissues
발표자
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초록
내용
Polyelectrolytes have properties that make them advantageous for the design of nanomaterials for drug delivery. These polymers are water-soluble, have a large number of easily modified reactive side chains for attachment of ligands, and can exhibit charge that can be designed to be sensitive to physiological conditions such as pH, redox conditions or the presence of specific enzymes. This capability makes charge a very enabling tool in the targeting of nanoparticles to specific tissues, as well as in adapting the transport of nanoparticles through the tissue matrix. Examples include charged polyamidoamine dendrimers for the penetration of drug into cartilage, with polyethyleneoxide to shield the amount of charge exposed. We also explore and exploit these interactions to target layer-by-layer nanoparticles to different cell types. The use of high throughput sampling of nanoparticle-cell interactions to understand nanoparticle-cell interactions and targeted uptake will also be discussed.