PEDOT:Poly(SSA-co-MA) Nanoparticle from Dual Acid-based Anionic Polyelectrolyte: Toward Efficient Photothermal Cancer Ablation
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초록
내용
To approach smart optical theragnosis for cancer, an easily processable heterocyclic conjugated polymer (poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate-co-maleic acid), PPMA) nanoassembly is manufactured in a surfactant-free one-step process without the usual multicoating process. Conjugated nanoassembly with self-doped structures provide strong absorbance in the near-infrared (NIR) range even with excellent stability (> 6 months) and shows a high photothermal conversion efficiency of 52.6% in organic photothermal nanoparticles. Through a simple immobilization with the anti-MDA-MB-231 antibody, the prepared biomarker-targetable PPMA nanoassembly demonstrates specific targeting toward MDA-MB-231, allowing NIR absorbance imaging and the efficient targeted photothermal damaging of MDA-MB-231-expressing cancer cells. In this study, an organic conjugated polymer-based nanoassembly based on a molecular approach with the most simplified fabrication method was reported and proved to be a very promising optical nanomaterial for optical cancer theragnosis.