Development of Peptide-Oligonucleotide Hybrids in Controlling Cell Proliferation
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All biological cells receive and respond to signals by selective binding events between membrane receptors and signaling molecules. Among signaling molecules, growth factors are essential for the cells to regulate their growth, migration, proliferation. However, irreversible denaturation, undesired degradation, and high production cost have always been major issues for the growth factors to be frequently used in biological research and cell-based therapy. To address this, we investigated the potential of peptide-oligonucleotide hybrids as alternative growth factors. When a key peptide was identified for the molecular interaction between a growth factor and its receptor, it was subsequently fused with a random oligonucleotide library; by in vitro selection, we can evolve the chemically synthesizable hybrid molecules to recognize the growth factor with high affinity and specificity and eventually induce and regulate cellular signal especially cell proliferation.