Hyaluronate-Black Phosphorus-Upconversion Nanoparticles Complex for Multi-Modal Theranosis of Skin Cancer
발표자
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초록
내용
Black phosphorus (BP) has been widely investigated for various biomedical applications with the unique 2D characteristics including its high photothermal conversion efficiency, biocompatibility, biodegradability, and photosensitizer. However, the low penetration depth of visible light has been the obstacle limiting further development of BP-based photomedicine. Here, we developed the hyaluronate-BP-upconversion nanoparticle (HA-BP-UCNP) complex for multimodal theranosis of skin cancer with photoacoustic (PA) bioimaging, photodynamic therapy (PDT), and photothermal therapy (PTT) via non-invasive transdermal delivery and NIR activation. HA in the complex facilitated the transdermal delivery of the complex into the tumor tissue. Upon 980 nm NIR light irradiation, UCNP has emission of UV-blue light which generate ROS by sensitizing the HA-BP-UCNP complex for PDT. In addition, 808 nm NIR triggered PTT for the apoptosis of tumor cells by the complex, and the PA of BP successfully visualized the non-invasive transdermal delivery of the complex into the mice’s skin.