Development of PDMS containing PMMA-Based Bone Cement to Treat Vertebral Fractures
발표자
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초록
내용
Vertebroplasty is commonly used technique to treat osteoporotic vertebral compression fractures. In this method, bone cement is injected into the defected vertebral body. Although the vertebroplasty using poly(methyl methacrylate) (PMMA)-based bone cement has been adopted in clinical practices as a gold standard, adjacent vertebral fractures caused by high modulus of injected bone cement is remained as a challenge. To solve the limitation of PMMA bone cement, we developed a PMMA bone cement containing polydimethylsiloxane PDMS as a plasticizer to reduce modulus. The PMMA/PDMS mixture was prepared by simple mixing, and PDMS in the bone cement was rapidly and homogeneously solidified by exothermic heat during PMMA polymerization. The SEM-EDS mapping, XRF analysis, mechanical property, injectability, cytotoxicity and Finite Element Analysis of PMMA/PDMS mixture were investigated. And, fatigue test using PMMA- or PMMA/PDMS-injected osteoporotic porcine bone was also conducted.