Self-assembly of phenazine derivatives for anticancer effects on hepatocarcinoma
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Phenazine derivatives have been reported as an effective anticancer compound against HepG2 cells, a hepatocarcinoma. However, phenazine derivatives are insoluble and self-assemble to a size of several tens of micrometers in an aqueous solution. Here we report enantiomeric amphiphilic phenazine derivatives and their self-assembled structures as chiral carriers for target molecules. The self-assembled structures could be controlled in different solvents. This approach provides a supramolecular prodrug concept for the next-generation drug delivery systems.