The antibacterial effect of a polyamidoamine dendrimer conjugated with short oligopeptides
발표자
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초록
내용
In this study, a new functional polymer was synthesized by grafting a short oligopeptide sequence to the surface of the second-generation polyamidoamine (PAMAM) dendrimer as an antibacterial agent. This method of synthesis proved simple and resulted in a high conjugation yield of the product. To determine its antibacterial potential, the polymer was subsequently analyzed via MALDI mass spectrometry, cytotoxicity assay, bacterial growth assay, colony-forming unit assay, membrane permeabilization assay, transmission electron microscopy, and biofilm formation assay. The polymer was found to exhibit low toxicity to non-cancerous NIH3T3 cells. Additionally, the polymer had an antibacterial effect on Escherichia coli and Staphylococcus aureus strains by interacting with and disrupting the bacterial cell membrane. Based on these findings, the polymer shows a potential as an antibacterial agent.