Hyaluronate-Au@Pt Bimetallic Nanoparticles for Non-Invasive Skin Cancer Theranosis
발표자
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초록
내용
Gold nanoparticles (AuNPs) with isotropic structures have contributed to the development of photothermal therapy (PTT) due to photothermal conversion efficiency and excellent photostability. However, isotropic AuNPs still have been limited for non-invasive cancer therapy and photoacoustic (PA) imaging. Here, we developed a hyaluronate-modified gold-platinum bimetallic nanoparticle (HA-Au@Pt) as a near-infrared (NIR)-mediated photothermal ablation agent for non-invasive cancer theranosis. The growth of Pt on the Au surface showed the SPR peak shift of AuNPs to the NIR region. In addition, HA promoted transdermal delivery into the skin barrier and facilitated the accurate PA imaging of tumors. Compared to the conventional PTT via injection, the HA-Au@Pt was non-invasively delivered into the cancer tissue and completely removed tumors in deep tissues under NIR illumination. An in vitro cytotoxicity test, in vivo PA imaging, antitumor therapy, and histological analysis successfully confirmed the non-invasive cancer theranostic effect of HA-Au@Pt with NIR illumination.