Improved Mechanical Properties and Anti-inflammatory Effect of Poly(L-lactic acid) Composites with Formation of Stereocomplex Structure and Surface-modified Magnesium Hydroxide
발표자
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초록
내용
Poly(L-lactic acid) (PLLA) is widely studied as a biomaterial due to its non-toxicity and elasticity. However, the PLLA is limited by a lack of mechanical properties and generation of acidic by-products as a biomaterial. In this study, the PLLA composites were combined with stereocomplex microparticles (SC) and surface-modified magnesium hydroxide (MH) nanoparticles with oligolactide. The SC formed by enantiomers PLLA and Poly(D-lactic acid) (PDLA) improved mechanical properties. Inflammation response by acidic degradation products decreased by pH neutralization effect of surface-modified MH. In addition, the PLLA composites displayed antibacterial effects and biocompatibility. This technology is expected to have a high potential for developing PLLA composites for various biomedical materials, such as biodegradable vascular scaffold (BVS).