Temperature and oxidation-responsive ion pair self-assembly composed of polyamidoamine and (phenylthio) acetic acid
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Ion pair self-assembly (IPSAM) was prepared using polyamidoamine (PAMAM) as a cationic hydrophilic polymer and (phenylthio) acetic acid (PTA) as a hydrophobic counter ion. The IPSAM was formed when the amino group to carboxylic group molar ratio was 0.5/9.5~3/7. The PTA content increased with increasing the PAMAM content. The ion pair was interface-active due to its amphiphilic property and exhibited the upper critical solution temperature (UCST) that increased with increasing the PTA content. After H2O2 treatment, The sulfide of PTA was oxidized resulting in the UCST and interfacial activity decrease. The IPSAM released its payload (i.e. nile red ) in response to temperature and oxidation. When the temperature was higher than UCST, IPSAM disassembled and released its payload. Upon oxidation, the UCST of IPSAM would decrease and undergo dissolution resulting in a promoted release