Nanotechnology-based CRISPR applications for gene editing and targeted therapy
발표자
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초록
내용
The clustered regularly interspaced short palindromic repeats (CRISPR) systems can enhance the outstanding potential of genetic therapies to address unmet needs in treating many diseases. Current approaches to CRISPR delivery rely primarily on viral delivery, which suffers from challenges including delayed expression, packaging limitations, and high off-target effects. Nanotechnology has received significant attention due to its unique properties of utilizing biomedical materials for therapeutic development and can contribute greatly to improving the efficiency of non-viral CRISPR delivery. Here we present non-viral genome editing systems based on the nano delivery platforms of the CRISPR/Cas9 for targeted therapy. These approaches have the potential for clinical applications as the treatment that could overcome the safety concerns of existing virus-based gene editing strategies.