Controlled Release of Antibiotics and BMP-2 using Gelatin Microspheres for Optimal Bone Regeneration
발표자
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초록
내용
Bone morphogenetic protein-2 (BMP-2) is the most notable growth factor in the field of bone regeneration, and is clinically used in various techniques such as maxillary bone grafting and bone induction regeneration. The conventional delivery protocol of BMP-2 is soaking biphasic calcium phosphate (BCP) blocks in a BMP-2 solution. However, the delivery of BMP-2 by conventional protocol is irregular and uncontrolled with most of the BMP-2 loaded on BCP being over-emitted after transplantation. In this study, the release of optimized growth factors and antibiotics was confirmed by using gelatin microspheres (GMSs) with different crosslinking degree by genipin to BCP blocks. The efficacy was evaluated by applying them to bulky defect models of the dog’s mandible and programmed BCP block induced a remarkable amount of new bones in 8 weeks compared to previous methods. We intend to precisely regulate the timing, rate, and capacity of release of antibiotics and BMP-2 in bone defects with a simple method.