Designing Plasmonic Janus Microgels for Charge-selective SERS-Based Detection of Target Molecules in Pristine Samples
발표자
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초록
내용
Strong electric field generated by metal nanoparticles (NPs) through surface plasmon resonance provides enhanced Raman signal of target molecules. However, metal surface is prone to contamination by adhesives like protein. In that sense, encapsulating metal NPs with protective layers obviates the pretreatment to remove impurities. Still, time-consuming steps such as preparation of metal NPs and microfluidic-based production are required. Here, plasmonic Janus microgel is designed using micromolding method. Plasmonic compartment in the form of gold NPs embedded in hydrogel is produced through simultaneous photoreduction and photocrosslinking by UV. Hydrogel allows the infusion of target molecules, excluding the infusion of protein. In order to enhance the SERS sensitivity, charged monomer concentrating the oppositely charged molecules is added to the hydrogel. Each color of photonic compartment indicates the charge of the hydrogel, enabling the charge-selective molecular detection.