Development of a superhydrophilic surface for antifouling and antithrombotic properties via layer-by-layer deposition
발표자
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초록
내용
Implantable medical devices, when exposed to blood, can cause acute thrombosis and inflammation due to adhesion and denaturation of plasma proteins, thereby impairing the performance of the medical devices. In order to overcome this problem, we developed superhydrophilic surfaces that are attracting attention for their excellent biocompatibility as well as reducing foreign-body reactions by prevention of adhesion and activate of non-specific proteins. Laponite (disk-shaped clay particle), Poly-L-lysine, and heparin, an antithrombotic agent, were alternately deposited based on electrostatic interactions using layer-by-layer assembly. When laponite was deposited, a change in physical properties such as gel was induced through self-assembly of laponite, and reduced cell attachment on the surface was confirmed. The developed coating is expected to be applicable to implantable medical devices including biosensors, or drug-releasing bio-devices.