Designing of Oxygen-supplying Syringes to Create Hyperoxia-inducible Hydrogels
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초록
내용
Recent trends in designing advanced hydrogels are to develop a bioactive matrix inducing in situ tissue regeneration via host tissue stimulation by their biophysicochemical stimuli. Among them, hyperoxia (> 21% pO2) is an emerging factor for tissue regeneration. While various oxygen (O2)-generating agents, such as peroxides with catalase, have been used to induce hyperoxia, excessive oxidative stress or cellular signaling suppression limits their use. Herein, we develop a catalase-immobilized syringe (Oxyringe) as a new O2-supplying platform by calcium peroxide-mediated catalase immobilization. Using Oxyringes, we form O2-releasing hydrogels, providing transient hyperoxia in vivo. Notably, our hydrogels promote wound healing and tissue regeneration, such as hemostasis, inflammation, proliferation, and remodeling phases in vivo. In sum, Oxyringe has great potential as advanced O2-supplying systems to create a hyperoxia-inducible matrix for in situ tissue regeneration.