Self-assembled PEGylated albumin nanoparticles (SPAN) for cancerchemotherapy and imaging.
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초록
내용
Paclitaxel (PTX) is a important chemotherapeutic agent used for the cure of a wide range of advanced cancers. But it was formulated with a mixture of oil and ethanol to enhance its solubility, which brings hypersensitivity reactions and neurotoxicity. Herein, a facile and oil-free method was used via a conjugate of human serum albumin (HSA) and poly(ethyleneglycol) (PEG) to prepare albumin-based PTX nanoparticles for efficient systemic carcinomas therapy. The PEGylation of HSA would provide stability to self-assembled nanoparticles containing hydrophobic drugs in a physiological fluid and HSA-based nanoparticles can accumulate in solid carcinomas via the improved permeation and retention (EPR) effect. When systemically administered in a mouse xenograft model for human breast cancer, the HSA-PEG based nanoparticle formulation exhibited an extended systemic circulation and increased intertumoral accumulation, resulting in a anticancer effect and prolonged survival of the animals.