Multi-functional hydrogels incorporating mineral-coated composite nano fibers with magnetic nanoparticles for photothermal therapy and bone tissue regeneration
발표자
()
초록
내용
Conventional photothermal therapy (PTT) for bone tumor focuses only on anti-tumor effects without consideration of regeneration of damaged bone tissue. To overcome these limitations, it is required to develop biomaterials enabling both cancer-therapeutic and tissue-regenerative outcomes. In this study, we developed a multi-functional composite hydrogels incorporating mineral-coated magnetic nanofibers for PTT and bone regeneration. First, we prepared mineral-coated poly-L-lactic acid (PLLA) nanofibers loaded with magnetic nanoparticles (mMF). Then, hydrogels incorporating mMF (G-mMF) were prepared, which lead to more than 80% cell death for osteosarcoma (MG-63). Meanwhile, G-mMF enhanced the osteogenic differentiation of human adipose-derived stem cells (hADSCs) by up-regulation of osteogenic genes. In conclusion, it is expected that the G-mMF would be multi-functional biomaterials with PTT and bone regeneration properties.