Repeated trauma or infection can induce excessive inflammation and result in delayed regeneration of skin tissue. In clinic, hydrogels have been used to cover wound areas due to their physical properties, however, they cannot actively regulate inflammation and angiogenesis for accelerated tissue regeneration. In this study, we developed nanocomposite gelatin methacryloyl (GelMA) hydrogels that can control both inflammation and angiogenesis. We prepared the tannic acid-strontium nanoparticles (TSrPs) and incorporated them into the GelMA hydrogels (G-TSrP). We confirmed the immunomodulatory effect of G-TSrP using macrophages. In addition, G-TSrP enhanced migration of endothelial cells and macrophages, and also increased expression remodeling genes of macrophages, allowing improved cell infiltration and biodegradation. Finally, G-TSrP accelerated tissue remodeling in vivo mouse model. In conclusion, G-TSrP would be a feasible material for skin tissue regeneration.