Fabrication and characterization of a powder-type anti-adhesion agent with improved tissue adhesiveness
발표자
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초록
내용
Adhesion between organs and tissues after surgery is the most common complication that causes symptomatic diseases, such as chronic pelvic pain. For adhesion prevention, it is necessary to develop an anti-adhesion agent that separates the injury site and the organs. In this study, the powder-type anti-adhesion agent made of hyaluronic acid (HA) and poly(vinyl pyrrolidone) (PVP) was fabricated. HA is a promising material because of its biocompatibility but has weak mechanical properties. To overcome these disadvantages, crosslinked HA powder using glyoxal as a crosslinker is designed as a novel powder-type adhesion barrier. PVP was incorporated into the chain of crosslinked HA as a semi-IPN structure to increase the adhesion of powder to the application site. From the animal study, it was confirmed that the powder-type HA-PVP has an excellent tissue adhesion prevention effect. Crosslinked HA-PVP powder could be proposed as a useful candidate for reducing unwanted post-operative tissue adhesion.